Well, as far as deployments , it’s seems that “most” implementations are rather normally okay, there’s times when memory issues did rise and troubleshooting this might be a real pain..
Mostly, i’d deal with a mail server that has no less then 16gb and is an all-in-one configuration, running 64bit Server 2003 sp2 with extra special care for all drivers , updates , prerequisites & page file configurations.
Usually, even if they run All roles + an Anti Virus product , while carefully setting backup & maintenance times, things go smooth.
Yet, there are times when the server is having issues, while troubleshooting is necessary of course, i’d rather go with the future spirit & just think my way up to Server 2008 .
Check out the Blog from mike in the Exchange Team blog it has some great links and more deep explanations..
server 2008 manages this issues out of box and the applications are far more compatible, easier life for all of us. really.
uh and yea i’m running vista sp1.